I have a M2P but never tried using it on a computer as the DJI sim requires Windows 10 and I have version 7 so I can't comment on "if" it will work.
The problem I see is that the M2P controllers throttle stick self centers which would mean the throttle in Velocidrone would be at half power when the throttle stick is centered. The M2P controller also only has about half of the physical travel distance a typical FRSky, FlySky, ect, controller stick would have which would make minor adjustments harder to accomplish.